A fourth season, now retitled Avengers: Secret Wars, was announced at San Diego Comic-Con. When a new version of the Cabal (consisting of Leader, Arnim Zola, Enchantress, Executioner, and Kang the Conqueror) is formed, Leader plans to scatter the captive Avengers across time and space with his Static Expander device. Black Panther forms the New Avengers to rescue them which consists of Ant-Man, Captain Marvel, Ms. Marvel, Vision, and Wasp. Even though Leader is defeated, Enchantress and Arnim Zola reveal that Leader is not the true leader of the Cabal as they activate the fail-safe that causes the Static Expander to send the captive Avengers across time and space. Before disappearing, Captain America instructs Black Panther's group to continue in their place until they can be found and brought home.

During New York Comic-Con, it was revealed that Hayley Atwell will reprise her role as Agent Peggy Carter from the Marvel Cinematic Universe in an episode that will see Carter teaming up with Captain America and Iron Man to stop Kang the Conqueror.